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387075

Very early onset versus pediatric onset inflammatory bowel disease: a prospective cohort analysis

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Autoinflammatory
Immunology
Pediatrics

Abstract

Background: Inflammatory bowel disease (IBD) in the pediatric age group is divided into two categories: very early onset IBD (VEO-IBD) and pediatric IBD (PIBD). The goal of this study was to determine the difference between the two entities concerning disease presentation, severity and treatment response. Methods: We conducted an observational prospective study that involved 70 newly diagnosed children with IBD, diagnosed using modified Porto criteria and followed up over a period of one year (35 VEO-IBD and 35 PIBD). It was conducted at the Pediatric Gastroenterology and Endoscopy Unit at Ain Shams University. Recruited cases were subjected to clinical assessment, and laboratory investigations including stool tests, full blood counts, and inflammatory markers in addition to ileo-colonoscopy and esophagogastroduodenoscopy. They were assessed initially and at follow-up for a total duration of one year for disease activity, treatment response, and disease relapse. Results: Gender distribution was similar among both VEO-IBD and PIBD groups. Rural residence (p=0.048), positive family history (p= 0.010), oral ulcers (p=0.022) and perianal skin tags (p=0.066) were more frequent among patients with VEO-IBD. Colonoscopy showed deeper ulcers in VEO-IBD (25.7%) than in PIBD (2.9%). Regression analysis showed that younger age (p=0.032) and high disease severity scores (p=0.011) were the main determinants of steroid non-responsiveness. Conclusion: Young age and severity score were the most predictive risk factors for steroid unresponsiveness in pediatric IBD

DOI

10.21608/ejpa.2024.312936.1075

Keywords

Paediatric Onset Inflammatory Bowel Disease, Very Early Onset Inflammatory Bowel Disease, ulcerative colitis

Authors

First Name

Radwa

Last Name

Abd elsalam

MiddleName

Mohamed

Affiliation

Pediatric department ain shams university Cairo egypt

Email

radwa-mohamed991@hotmail.com

City

-

Orcid

-

First Name

moustafa

Last Name

El-Hodhod

MiddleName

Abdel Aziz

Affiliation

Pediatric department Ain shams university Cairo Egypt

Email

mostafaelhodhod@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Hamdy

MiddleName

Mohamed

Affiliation

Pediatric department Ain shams university Cairo Egypt

Email

a_hamdy13@med.asu.edu.eg

City

-

Orcid

-

First Name

Ola

Last Name

Nada

MiddleName

Hassan

Affiliation

Pathology department Ain sham university Cairo Egypt

Email

dr_olanada@yahoo.com

City

-

Orcid

-

First Name

Dina

Last Name

swilem

MiddleName

Abdel Hamid Nabhan

Affiliation

Pediatric department Ain sham university Cairo Egypt

Email

dswilem@gmail.com

City

-

Orcid

-

Volume

22

Article Issue

2

Related Issue

50888

Issue Date

2024-10-01

Receive Date

2024-08-16

Publish Date

2024-10-01

Page Start

81

Page End

89

Print ISSN

1687-1642

Online ISSN

2314-8934

Article File

EJPA_Volume 22_Issue 2_Pages 81-89.pdf

PDF . 323.5kB

Link

https://ejpai.journals.ekb.eg/article_387075.html

Detail API

https://ejpai.journals.ekb.eg/service?article_code=387075

Order

387,075

Type

Original Article

Type Code

643

Publication Type

Journal

Publication Title

The Egyptian Journal of Pediatric Allergy and Immunology

Publication Link

https://ejpai.journals.ekb.eg/

MainTitle

Very early onset versus pediatric onset inflammatory bowel disease: a prospective cohort analysis

Details

Type

Article

Created At

24 Dec 2024