The immune system is essential in protecting the human body against harmful bacteria, viruses, and fungi. Deficiencies in immune defenses can open the door not only to infections but also to the development of tumors. This article provides a concise overview of the key immune-modulating properties of several commonly used herbs and their active ingredients, including purple coneflower (Echinacea), black cumin (Nigella sativa), turmeric (Curcuma longa), ginger (Zingiber officinale), and cinnamon (Cinnamomum zeylanicum). These plants were chosen for their popularity, ease of access as supplements, known immune-boosting effects, and extensive scientific investigations on their active ingredients and extracts. Various natural herbs and spices have demonstrated significant immunomodulatory properties. This immune-enhancing impact is ascribed to the presence of bioactive phytoconstituents in these remedies, including polyphenols, terpenoids, β-glucans, and vitamins. Bioactive compounds found in natural ingredients directly improve the cytotoxic activity of natural killer cells, macrophages, and neutrophils, thereby strengthening the immune response. Additionally, many phytoconstituents possess powerful anti-inflammatory, antimicrobial, and antioxidant properties, protecting cells from damage and promoting overall immune function. In conclusion, this review explores widely recognized herbs with immune-boosting properties. The findings are promising, indicating that these herbs could be beneficial as preventative measures in natural medicine.