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321394

Value of Urinary Transferrin, Urinary Ceruloplasmin and Urinary Neutrophil Gelatinase Associated Lipocalin as biomarkers in Pediatric Lupus Nephritis

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Autoimmunity
Pediatrics

Abstract

Background: Lupus nephritis is an important cause of pediatric lupus morbidity and mortality. We sought to investigate the value of urinary transferrin (uTF), urinary ceruloplasmin (uCP) and urinary Neutrophil Gelatinase Associated Lipocalin (uNGAL) as non-invasive biomarkers of renal involvement in pediatric SLE. Methods: We conducted a comparative cross-sectional study over a period of 6 months at the Pediatric Allergy, Immunology and Rheumatology Unit, Ain Shams University. The study included a total number of 60 subjects; 40 patients with SLE and 20 age and sex-matched healthy subjects. Urinary levels of the three biomarkers (uTF, uCP and uNGAL) were measured by ELISA, in relation to other lupus clinical, urinary and serum parameters. Results: The studied patients had mean age 14.35 ± 2.3 years and 85 % (n = 34) were females. Among patients with LN (n=20), 8 (40%) had class II, 8 (40%) class III and 4 (20%) class IV LN. We observed significantly higher uTF levels, uCP expression and uNGAL levels among lupus patients compared to controls (p<0.001). In addition, the 3 studied biomarkers were significantly higher among LN group compared to SLE without LN (p<0.001). Levels of uTF, uCP and uNGAL showed significant positive correlations with 24-hour urinary proteins, serum creatinine and significant negative correlations with serum albumin, and estimated Glomerular Filtration Rate. Conclusion: Urinary TF, uCP and uNGAL might serve as non-invasive biomarkers of LN in pediatric and adolescent SLE. Their significant elevation in active cases may reflect a potential predictive value of renal flares and may serve as a valuable affordable tool in the follow-up of LN.

DOI

10.21608/ejpa.2023.321394

Keywords

Urinary Transferrin, ceruloplasmin, biomarkers, NGAL, lupus nephritis

Authors

First Name

Mohammad

Last Name

Sharaf

MiddleName

A.

Affiliation

Pediatric Nephrology Unit, Ain Shams University

Email

-

City

-

Orcid

-

First Name

Elham

Last Name

Hossny

MiddleName

-

Affiliation

Professor of Pediatrics Pediatric Allergy, Immunology and Rheumatology Unit, Children's Hospital, Ain Shams University, Cairo, Egypt

Email

elham.hossny@gmail.com

City

-

Orcid

-

First Name

Nancy

Last Name

Wahba

MiddleName

S.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Ain Shams University

Email

nancy_samir@live.com

City

-

Orcid

-

First Name

Mohammad

Last Name

Hegazy

MiddleName

A.

Affiliation

Ministry of Public Health Hospitals, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Abdulrahman

Last Name

Warsame

MiddleName

A.

Affiliation

Public Health Hospital, Benadir, Somalia.

Email

-

City

-

Orcid

-

First Name

Sara

Last Name

Abdelmottaleb

MiddleName

E.

Affiliation

Ministry of Public Health Hospitals, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rasha

Last Name

El-Owaidy

MiddleName

-

Affiliation

Associate professor of Pediatrics and Pediatric Allergy, Immunology and Rheumatology, Ain-Shams University, Egypt. Member, ESPAI, WAO, EAACI, ESID, ASID

Email

rasha2hasan@gmail.com

City

-

Orcid

0000-0002-5609-4160

Volume

21

Article Issue

2

Related Issue

43935

Issue Date

2023-10-01

Receive Date

2023-08-04

Publish Date

2023-10-01

Page Start

47

Page End

55

Print ISSN

1687-1642

Online ISSN

2314-8934

Article File

EJPA_Volume 21_Issue 2_Pages 47-55.pdf

PDF . 225.4kB

Link

https://ejpai.journals.ekb.eg/article_321394.html

Detail API

https://ejpai.journals.ekb.eg/service?article_code=321394

Order

321,394

Type

Original Article

Type Code

643

Publication Type

Journal

Publication Title

The Egyptian Journal of Pediatric Allergy and Immunology

Publication Link

https://ejpai.journals.ekb.eg/

MainTitle

Value of Urinary Transferrin, Urinary Ceruloplasmin and Urinary Neutrophil Gelatinase Associated Lipocalin as biomarkers in Pediatric Lupus Nephritis

Details

Type

Article

Created At

24 Dec 2024