Background: The patients' spent time on the ventilator and its associated difficulties can be minimized through the efficient planning and implementation of nursing interventions to assess the patient's readiness for ventilator weaning. The assessment of nursing interventions' efficacy on weaning from mechanical ventilation has not been adequately performed. This study aims to investigate the effect of implementing nursing intervention on weaning from mechanical ventilators based on a burns wean assessment program. Method: There are 88 mechanically ventilated patients in this quasi-experimental study (44 patients in each intervention and control group). It was carried out at the Mansoura University Hospital's intensive care unit for anesthesia in Egypt. Two methods were used to gather data: an assessment tool for patients who were mechanically ventilated, and evaluation tools that were based on the patient's ventilation indicators and the Burns' Wean Assessment Program checklist. Results: Compared to the control group, the majority of the intervention group was effectively weaned off of intrusive mechanical ventilation during the trial of spontaneous breathing on the first try. When comparing the intervention group to the control group, the intervention group's length of stay in the critical care unit and ventilation was shorter. Conclusion: The intervention group displayed higher weaning scores than the control group. Therefore, integration of the nursing intervention based on the Burns Wean Assessment Program of mechanically ventilated patients is recommended to improve weaning success and reduce the duration of mechanical ventilation.