Background: Minor discomforts are frequently common health problem that disturbance pregnant women, but not threating life. Aim: the current study aimed to evaluate the effect of Tele-nursing services on pregnant women regarding minor discomforts. Subjects and Methods: A quasi- experimental design was used. Sample: A purposive sample, 120 pregnant women included in this study. Setting: the study was conducted in antenatal clinic at Ain Shams University Maternity Hospital. Tools: Tool I A structured interview questionnaire. Tool II self-care reported practice checklist Tool III Women satisfaction Likert scale. In addition to, Supportive material (Electronic Arabic booklet). Results: The study revealed that there was a statistically significant improvement in total knowledge and self-care practice score of pregnant women related minor discomforts at post intervention compared to pre intervention. Conclusion: There was a positive effect of telenursing services on improving pregnant women knowledge and self-care practice regarding minor discomforts during pregnancy among study group compared to control group. in addition, the majority of study group were satisfied regarding using telenursing services at post-intervention. Also, there was a statistically significant correlation between total knowledge score and total self-care practice score regarding minor discomforts among study group at post-intervention(p-value<0.05). Recommendations: Implementation of telenursing   services at natal clinic of different health care setting for improving knowledge and practice related to minor discomforts among pregnant women. Awareness programs should be developed to raise women's knowledge and practice regarding minor discomforts of pregnancy via telenursing services and increase women's satisfaction regarding using telenursing services to improve obstetrics services.