Background: Following significant abdominal and pelvic surgery, venous thromboembolism—which includes pulmonary embolism and deep vein thrombosis—is a dangerous consequence that doubles the risk of morbidity and death. Aim: To evaluate the efficacy of educational sessions on venous thromboembolism prevention and emotional status among Women having Major abdomino-pelvic surgery. Design: A quasi-experimental research design pre and post-one group was used to achieve the aim of this study. Setting: The study was conducted in study was conducted at the gynecological department and outpatient clinic (for post-operative follow-up) at Mansoura University Hospital. This setting was selected due to the high flow rate of cases additionally it serves the biggest region of the population. Sample:  A convenient sample of 100 women with gynecological tumors undergoing major abdomino-pelvic surgery was recruited for this study was collected during six months aged (20-65) years were included. Tools of data collection: Four tools were utilized in this study including Tool 1: An interview scheduled questionnaire, Tool 2: Deep vein thrombosis risk factors assessment sheet, Tool 3: Deep vein thrombosis assessment sheet, and Tool (4): Anxiety and Depression Scale (HADS). Results: there were statistically significant differences and improvements in all items of knowledge about venous thromboembolism among the studied women having major abdomino-pelvic surgery pre and post-educational session's implementation. Most (96%) women with major abdomino-pelvic surgery had unsatisfactory total knowledge scores in the pre-test phase. In comparison, 84 % of them had total satisfactory knowledge scores post-educational session implementation. There were statistically significant differences and improvements in all items of compliance with VTE preventive measures among the studied women having major abdomino-pelvic surgery pre and post-educational session's implementation. Also, demonstrates that there was a statistically significant difference in the Hospital Anxiety and Depression scale scores that were reported among the studied women having major abdomino-pelvic surgery pre and post-educational session's implementation. Conclusion: Educational session implementation has a positive effect on Venous Thromboembolism Prevention and emotional status among Women having Major abdominal pelvic Surgery. Recommendations: Educational sessions should be implemented as an essential part of routine care for all women having major abdomino-pelvic Surgery.