Background Chronic diseases are the dominant cause of global morbidity and mortality, especially in developing countries. Aim: This study aimed to investigate perception of contraceptive methods among women with chronic diseases Research design: Descriptive analytical study was used in this study. Sample A purposive sample was utilized and takes 210 women with inclusion criteria. Setting: This study was conducted at outpatient family planning and gynecology clinics, at Maternity Hospital in Ain Shams University. Data collection: include: 2Tools: Tool I A Structured interviewing questionnaire Tool II Likert attitude scale to assess attitude toward utilization of contraceptive methods among women with chronic diseases. Results This study showed that, (67.6%) of the studied women have unsatisfactory level of total knowledge about contraceptive methods during chronic diseases. While, (32.4%) of them have satisfactory level of total knowledge. Also, (57.1%) of the studied women have negative attitude regarding contraceptive methods during chronic diseases. While, (42.9%) of them have positive attitude. Conclusion: More than two thirds of the studied women had unsatisfactory level of total knowledge about contraceptive methods during chronic diseases. Also, more than half of the studied women had negative attitude regarding contraceptive methods during chronic diseases. Recommendations: Design an educational program about the suitable contraceptive methods for women with chronic diseases to avoid the risk of unintended pregnancy during their chronic diseases. Conduct an awareness campaign about the importance of contraceptive methods for women with chronic diseases through mass media and in public places.