Background: Patients surviving the intensive care unit frequently develop memory gaps or distorted memory and unpleasant recall after discharge, this memory usually associated with anxiety, depression and post traumatic disorder that affected negatively on quality of life.  Aim of study: Was to assess distorted memory among the patients in intensive care unit and its related factors. Design: Descriptive exploratory. Setting: Medical intensive care unit at El-Demerdash Hospital affiliated to Ain-Shams University. Subjects: purposive sample included 98 patients. Tools: 1- Patients structured interview questionnaire including demographic characteristics, medical data, acute physiology and chronic health evaluation for assessing disease severity level and hospital anxiety and depression scale. 2- Patients distorted memory related factors assessment tool. 3- Distorted memory assessment tool and 4- Mini-Mental State Examination tool. Result: revealed that, the studied patients total mean scores regarding disease severity, anxiety & depression, distorted memory affecting factors, distorted memory and cognitive disturbance were 11.49±5.40, 15.83±3.29, 16.92±3.13, 45.17±6.32, 12.26±3.66 and 21.67±4.21 respectively. Conclusion: Majority of the studied patients had moderate level of disease severity, highest percentage of them had severe depression and anxiety level, more than three quarter of them reported high affecting factors on their distorted memory. As well, more than half of them had bad/distorted memory and severe cognitive disturbance. Additionally, there were a highly significant positive correlation between all the studied variables. Recommendations: suggesting evidence-based strategies to avoid developing distorted memory among the patients in intensive care unit.