Background: Providing care to children with hearing loss can be a difficult task for family caregivers, resulting in physical, emotional, and financial pressures. Informal caregivers require support to effectively sustain their role. Aim: This study aimed to assess knowledge, caregiving practices, and adjustment among family caregivers of children having hearing loss. Design: A quasi-experimental was used to achieve the aim of this study. Setting: The study was conducted in the outpatient Speech clinic affiliated with the faculty of Post Graduate Childhood Studies at Ain Shams University. Subject: A purposive sample of 40 family caregivers of children with hearing loss. Tools of data collection: 1) Demographic information was collected, as well as data from several scales, including the 2) Parent Knowledge Scale, 3) Family Caregivers' Reported Practices Questionnaire, and 4) Adjustment Scale. Results: The results of this study showed there was a significant difference in the knowledge, practice, and adjustment among family caregivers of children having hearing loss. Conclusion: The current study concluded positive impact on the knowledge, caregiving practices, and adjustment of family caregivers of children with hearing loss. Recommendation: The current study recommended that educational training programs among family caregivers of children having hearing loss to enhance knowledge, caregiving practices, and adjustment of family caregivers of children with hearing loss, as well as regular updates to ensure ongoing improvement in the knowledge, practices, and adjustment of family caregivers caring for children with hearing loss.