Background: Social media addiction is defined as being overly concerned about social media applications. Resilience can work as a psychological protective factor against social media addiction among nursing students. Psychological resilience is defined as the ability to maintain a state of normal equilibrium in the face of extremely unfavorable circumstances. Aim: This study aimed to assess the relationship between social media addiction and psychological resilience among university nursing students. Design: A descriptive relational study design was utilized in this study. Setting: This study was carried out at the Faculty of Nursing-Al-Azhar University. It includes six scientific departments. Subjects: A convenient sample of 411 university nursing students enrolled in the first, second, third and fourth patch, academic year (2023-2-24). Data collection tool: Data was gathered using the following 1) Structured interview questionnaire to assess university nursing students' demographic data; 2) Social media addiction scale; and 3) psychological resilience scale. Results: Data analysis shows that less than two-thirds of the studied subjects were not at high risk for social media addiction. Also, less than three fifths of the studied subjects had a moderate level of psychological resilience while less than two-fifths of them had high levels of psychological resilience. There was a negative correlation between social media addiction and psychological resilience among university nursing students. Conclusions: University nursing students with a moderate level of psychological resilience were not at high risk for social media addiction. Recommendations: Designing and implementing educational programs about how to reduce social media addiction, as well as implementing periodic scientific seminars for university nursing students about strategies to promote psychological resilience.