Background: Organizational silence one of these problems which undoubtedly lead to work alienation among staff and must be faced and managed well. Aim of the study: The current study aimed to assess the influence of organizational silence on work alienation among staff nurses. Design: A descriptive correlational design was used. Setting: The study was conducted at Sohag general Hospital. Subjects: the study subjects include 225 out of 400 staff nurses. Tools: Two tools were used to achieve the aim of this study namely organizational silence scale and work alienation scale. Results: Two fifth (40%) of staff nurses had high perception regarding total organizational silence, while near two fifth (38.2%) of them had high perception regarding total work alienation and there was a highly statistically significant positive relation (R=0.347, B=0.198, p=0.00) between organizational silence and work alienation among staff nurses. Conclusion: there was highly significant statistical positive correlation between total organizational silence and total work alienation among staff nurses. Recommendations: Implement regular feedback mechanisms, to allow nurses to express their thoughts and concerns. Further research is recommended as studying the effectiveness of interventions, in reducing work alienation stemming from silence.