Background: Patient with eczema can often have physical problems e.g. Bacterial skin infections and viral skin infections. It's also possible for eczema to become infected with the herpes simplex virus, which normally causes cold sores that effect on patient quality of life and their relation with other family member and their colleagues in the work. Aim: This study aimed to assess the quality of life for patients with eczema. Research design: A descriptive exploratory design was used in this study. Subjects: Purposive sample of 74 patients from both gender were participated. Setting: The study was conducted in Dermatological clinic at Dairut Central Hospital in Assiut. Tools: Four tools were used in this study: I: Patients interviewing questionnaire. II: Observational check list to assess patients' level of practice regarding care of eczema. III: SCORAD scale was used to assess the level of severity of eczema, Tool IV: Dermatology life quality index (DLQI) and Tool IV:  Hospital anxiety and depression scale. Results: 36.5% of the studied patients had good level of knowledge of eczema, 56.8% of the studied patients had negative attitude toward eczema, 68.9% of the studied patients had unsatisfactory level of practice and 18.9% of them had high level of quality of life. Conclusion: More than one third only of the studied patients had good level of knowledge regarding eczema and more than half of the studied patients had negative attitude regarding eczema. While, less than half of them had positive attitude about eczema. Recommendation: Providing health education about food, personal, and environmental hygiene for both patients and their family. Planning and conducting health education programs in outpatient clinic for patient about the causes and prevention of eczema episode. Regular follow up is needed to ensure the efficiency of management and to diagnosis new site of eczema.