Background: Asthma is a worldwide health problem and a major disease affecting all age groups .The aim of the study: Was to assess health related quality of life for patients with bronchial asthma. Research design: A descriptive exploratory design was utilized. Setting: The study was conducted at chest outpatients' clinic of El Sheikh Zayed Al Nahyan Hospital, Cairo, Egypt. Sample: A convenient sample composed of (50) adult patients with bronchial asthma. Tools: Three tools were used. First tool: Structured interviewing questionnaire for patients with bronchial asthma was used, including two parts: Part (I) Socio-demographic characteristics of patients, part (II) Knowledge assessment sheet for patients with bronchial asthma .Second tool: Asthma Control Questionnaire (ACQ). Third tool: Asthma Quality of Life Questionnaire (AQLQ). Results: Slightly less than three quarters of the studied patients had uncontrolled level over their disease. There was a significant statistical positive correlation between total level of knowledge and total level of quality of life at P-value =0.036 and there was a significant statistical positive correlation between total level of quality of life and total level of asthma control at P-value =0.040 among the studied patients. Conclusion: The majority of the studied patients had unsatisfactory total knowledge related to bronchial asthma disease. While regarding total level of health related quality of life, more than two fifths of them had a poor level, less than one third of them had average level, and more than one quarter of them had a good level. Recommendations: Increasing the awareness of the patients about the importance of maintaining health related quality of life of patients with bronchial asthma disease through campaigns, mass media and social networks. Further studies including larger samples of bronchial asthma patients from different geographical areas to generalize the results in Egypt.