Family planning is still a crucial public health intervention, thus nurses should play a bigger role in filling the gap by offering training that will increase their ability to satisfy women's health demands. This study aimed to determine the effect of structured-based training on nurses' knowledge and practices regarding modern contraceptive methods. Study design: A quasi-experimental one group pre-immediate and post-test design was utilized. Study setting: A family planning clinics of Tanta University Hospital, El-Menshawy General Hospital, Doctor Mohamed Mashally Medical Center, Segar Medical Center, Kohafa Medical Center, Satouta Medical Center, and El-Agezy Medical Center. Study Subjects: All available nurses (50) who were working in previously mentioned settings. Study Tools: Two tools were used for data collection, nurses' knowledge regarding modern contraceptives questionnaire, and nurses' practices regarding modern contraceptive methods by using observational checklist. Results: Following the implementation of the structured-based training, nurses' mean knowledge and mean practices scores about current contraceptive methods increased both immediately and one month later, with a statistically significant difference. Conclusion: The implementation of structured-based training has led to a statistically significant positive improvement in knowledge and practices of the studied nurses about modern contraceptive methods, hence fulfilling the research hypothesis. Recommendations: Nurses should have access to clear, ongoing education and in-service training programs to remain up-to-date on modern contraceptive methods and enhance their practices.