Background: Organizational silence is a phenomenon that occurs in organizations when employees purposefully withhold information and opinions about the organization, it has joint effect on job performance ratings, and that lead to burnout. Aim: This study was aimed to assess organizational silence as perceived by staff nurses and it influence on their burnout. Research design: A descriptive, correlational design was used. Setting: The study was conducted at Ain Shams Hospital affiliated to Ain Shams University Hospitals. Subjects: A simple random, the subjects of this study were included 169 staff nurses out of 300 staff nurses Tools: Data were collected by using Organizational Silence scale and Maslach Burnout Inventory. Results: Revealed that one fifth of staff nurses had a high perception level regarding total organizational silence. Also, slightly less than two thirds of them had moderate perception level regarding total organizational silence. While, minority of them had low perception level regarding total organizational silence. Moreover, revealed that more than one fifth of staff nurses had a high perception level regarding total burnout. Also, slightly less than two thirds of them had moderate perception level regarding total burnout. While, minority of them had low perception level regarding total burnout. Conclusion: There was a highly significant correlation between total of organizational silence and burnout among staff nurses. Recommendations: Conduct periodical meeting between hospital managers and staff nurses for discussing work problem and develop solutions for each problem, developing effective positive work environment among nursing staff, and developing clear instructions and protocols to increase transparency and addressing organizational silence.