Background: Systemic lupus erythematosus is an autoimmune and inflammatory disease with diverse multisystem involvement. It is imperative for adolescents to strengthen their education in order to have adequate self-care. Aim: This study aimed to evaluate the effect of self-care management program on awareness of adolescents suffering from systemic lupus erythematous. Design: This study applied a quasi-experimental design. Setting: The study was undertaken at Inpatient Pediatric Department, Rheumatology outpatient clinics of Beni-Suef University Hospitals. Sample: A convenience sample of fifty adolescents. Data collection tools: Three instruments were utilized.  I: A Structured Interviewing Questionnaire incorporating three sections: personal characteristics, medical data and knowledge assessment of studied adolescents II: Adolescents' reported practices checklist III: Adolescents' attitude likert scale. Results: Following application of the self-care management program, majority of the adolescents displayed satisfactory knowledge, competent practice, a positive attitude. A highly notable significance was exhibited between pre and post self-care management program regarding all variables. Conclusion: The self-care management program positively affects awareness of adolescents with systemic lupus erythematosus. Recommendation: On-going implementation of specialized self-care training programs in systemic lupus erythematosus to enrich adolescents' awareness.