Background: Mindfulness might help nurses in dealing with conflicts, work and family demands conflict with one another(work-family conflict). Aim of this study: assess mindfulness  and it's relation to work family conflict among staff  nurses DesignTo conduct the study, a descriptive, correlational design was chosen. Setting: The study was conducted at Ain Shams University hospital, which is affiliated to Ain Shams university hospitals Subject: The subjects of this study involved184out of 350 staff nurses. Data collection tools: There were two tools were used to gather the data. namely: Five-Facet Mindfulness Questionnaire (FFMQ), and Work-family Conflict Scale (WFCS). Results: shows that over than half of staff nurses had a low level of mindfulness regarding observing dimension and more greater than one-third have moderate level regarding non-reactivity dimension. While only 9.3%of them have high levels. Also, shows that more than half of studied nurses had a high-level regarding behavior-based FIW dimension. Also, more than one-third have moderate level regarding behavior-based WIF dimension. Over 50% of the studied staff nurses have a high level of work family conflict. Conclusion: there was a highly negative significant correlation between mindfulness and work family conflict within the staff nurses .Recommendations: Develop and deliver a training program and workshops to assist nurses in developing a more mindful lifestyle and creating a positive work environment to enhancing in work-life balance will increase one's job satisfaction and decrease one's intention to quit.