Background: Diabetic foot ulcers are among the most common complications of diabetes mellitus and associated with psychological disorders mainly anxiety and depression; therefore, psychological interventions are crucial. Aim: to investigate the effect of psychological interventions on depression and anxiety symptoms among patients with diabetic foot ulcers. Setting: The study was carried out at the outpatient clinic for blood vessels at Alhrar Hospital in Zagazig city, Sharkia governorate, Egypt. Subjects: A purposive sample of 60 adult patients suffering from diabetic foot ulcers. Research design: a one-group quasi-experimental design that measures change in depression and anxiety symptoms pre- and post-psychological interventions. Tools: Three tools were utilized to collect the necessary data, namely a patient assessment form, the Hamilton anxiety rating scale, and the Hamilton depression rating scale. Procedure: The psychological interventions was developed by the researchers and implemented to the experimental group. Participants were divided into six groups; each group consisted of ten patients. The program consisted of 12 sessions and was implemented during the morning shift, twice daily, three times per week, one session for each group every week for three months. Results: Significant improvement was revealed after the intervention in regular treatment and ulcer care. Most of the patients showed post-intervention Wagner grade improvement. There was significant improvement in total anxiety score and depression at the post-implementation phase. A significant positive, strong correlation was found between patients' anxiety and depression scores. The study intervention was a negative predictor of the anxiety and depression scores. Conclusion: The psychological interventions were effective in improving the depression and anxiety symptoms among patients with diabetic foot ulcers, with improvement in ulcer grades. Recommendation: The study recommends the use of the developed psychological intervention in the study settings and in similar ones. The psychological state of any patient with diabetes, especially those suffering from diabetic foot, should be closely and regularly monitored.