Background: Diabetic wounds are considered a medical, psychological, social, and economic burden and are associated with decreased patients' quality of life. Vacuum-assisted closure (VAC) therapy is widely established in managing several types of wounds. VAC therapy is a method used for wound management that enhances overall wound healing. Aim: Assess the effectiveness of vacuum-assisted closure therapy on diabetic wound management. Subjects: - A purposive sample of (n=50) patients with diabetic wounds. Research design: A quasi-experimental design using a one-group posttest-only design was conducted in this research. Setting: The study was conducted at Alexandria Main University Hospital, in the inpatient surgical department. Tools: Wound Healing Assessment Tool (WHAT) was used for data collection. Results: Most patients who had partial wound healing after one month of VAC dressing application. There was a statistically significant wound healing improvement related to wound size reduction, granulation tissue formation, decrease in wound exudates amount, absence of wound odor, absence of local wound infection signs, and absence of tissue necrosis. Conclusion: VAC therapy has a significant impact on diabetic wound healing and had promising results with Diabetic wound management exhibiting faster wound healing. Most patients had partial wound healing after one month of VAC application. Recommendations: Vacuum-assisted closure Therapy is recommended for difficult and non-healing wounds that do not respond to traditional dressing techniques.