Background: Glaucoma is a leading cause of irreversible visual impairment worldwide. Glaucoma comprises a set of heterogeneous diseases that differ in their causes, risk factors, symptoms, and treatment. The discussion takes the biopsychosocial needs of patients with glaucoma to facilitate connections to holistic patient care. Aim: To assess the biopsychosocial and educational needs of patients with glaucoma. Design: Descriptive exploratory design was utilized to meet the aim of this study. Setting: This study was conducted at the outpatient clinic of Damanhour Ophthalmology Hospital in Al-Bahira, affiliated with the Ministry of Health. Subjects: A convenient sample of all available adult patients with glaucoma (90 patients) who attended the previously mentioned setting for six consecutive months. Tools for data collection: Tool I: Patient`s interviewing questionnaire. Tool II: Lawton instrumental activities of Daily Living (IADL).Tool III: Feelings of depression, Anxiety, and Stress Scale-21 Items (DASS-21). Tool IV: Social dysfunction rating scale. Results: (62.2%) of the studied patients had unsatisfactory education about glaucoma. And (77.8%) of the studied patients were independent regarding daily living activities. Also (83.3%) had a mild level of total psychological needs. Additionally, (96.7%) of the studied patients had mild levels of social dysfunction. Conclusion: Most of the studied patients had unsatisfactory educational needs about glaucoma. More than three-quarters of the studied patients were independent regarding daily living activities. At the same time, more than four-fifths of the studied patients had a mild level of total psychological needs. Also, most of the studied patients had a mild level of total social dysfunction. Recommendation: A simplified and comprehensive booklet should be available for patients with glaucoma. Including the most information regarding the disease, therapeutic regime, and self-care, and cover the biopsychosocial needs of the glaucoma patients.