Background: Plasma exchange (PE) is a highly efficient therapy for Myasthenic Gravies. Nurses are playing an energetic role in prevention, early recognition of complications and deliver appropriate care and educating patient how to manage self-care management of their treatment and decrease complications of plasma exchange. Aim of the study: was to evaluate the effect of self-care management protocol on outcomes of patients with Mythenia gravies undergoing plasma exchange. Study design: A quasi-experiment study design was used to conquer this aim. Setting: This study was conducted at the therapeutic plasma exchange room in the Hemodialysis unit in Ain Shams university Hospital affiliated to Ain Shams University. Sample: A Purposive sample of 60 patients with Myasthenia Gravies undergoing plasma exchange. Tools of data collection: Data were collected using four tools:1-Patients' with Mythenia gravies interview questionnaire, 2- Patients' with Mythenia gravies knowledge questionnaire related to plasma exchange, 3- Myasthenia Gravis Activities of Daily Living scale (MG-ADL) and 4- Complications checklist of plasma exchange. Results: This study illustrates a highly statistically significant difference between study and control groups regarding incidence of complications Post Implementation of Self-management protocol P <0.001. Also, displays a significant positive correlation between total satisfactory knowledge and incidence of complications as well as Mild daily living scale pre/post and follow up post implementation of Self-management protocol among both groups at p= <0.001. Conclusion: study resolved that there was an enhancement in knowledge, activities and outcomes of patients with Mythenia gravies undergoing plasma exchange after implementation of self-care management protocol. Recommendation: Accessibility of self-care management booklet in all settings of plasma exchange.