Background: Because of hormonal fluctuations, cyclic mastalgia is a discomfort associated with menstruation. Aim: to assess the effect of PLISSIT model _based counseling on pain, sexual function, and quality of life (QOL) in fertile women with cyclic mastalgia. Research design: a quasi-experimental pretest/posttest research design was conducted. Setting: This study was conducted at the gynecological outpatient clinics at Minia Maternity and Children University Hospital in Minia City. Subjects: a purposive sample of eighty married, fertile women who met the mastalgia criteria, defined as having a pain scale score of at least four. Tools: data were collected via five tools: the structured interview questionnaire, Cardiff pain chart, the Pain Rating Index- scale value (VAS), the Female Sexual Function Index (FSFI), and the World Health Organization Quality of Life-BREF questionnaire. Results: there is a statistically significant difference in relation to the impact of the PLISSIT model-based counseling as the number of days with no pain increased from 15.39±1.68 pretest to 27.71±1.25 posttest, and the number of days with severe pain decreased from 8.14±1.96 pretest to 0.40±0.52 posttest(p=0.000**). Additionally, the percentage of women with low sexual activity decreased from (66.3%) pretest, to (0.0%) posttest, and the percentage of women who had high sexual activity increased from (0.0%) pretest to (65.0%) posttest (p <0.001). Furthermore, (67.50%) of the study women had poor quality of life pretest as compared with (97.70%) of them having good quality of life posttest. Conclusion: the PLISSIT model_ based counseling reduced pain, had a curative effect on sexual function, and was effective in correcting these conditions, significantly increasing the overall life quality scores. Recommendation: it's recommended to compare the efficacy of PLISSIT model-based counseling with other counseling and therapeutic models in managing cyclic mastalgia and improving sexual function and quality of life.