Background: The potential harmful effects of smoking are not only affected internal organs but may have great effects on skin age. The aim of this study was to assess the level of knowledge and awareness among Najran City, Saudi Arabia residents regarding the association between smoking and premature skin aging. Methodology: A cross-sectional and community-based study was conducted in Najran city. A simple random sampling technique was used for determining the sample size. A semi-structured and self-administered electronic questionnaire was utilized for collecting data. Data analysis was conducted using Microsoft Office Excel 2007 and version 21 of the Statistical Package for the Social Sciences. The Chi-square test was applied, with a significance level of P < 0.05. Results: A study conducted among 251 Najran city residents revealed that nearly three quarters of the participants were males, while more than one quarter of them were females. The majority were aged 20-24 years in addition most of them 80.9% were non-smokers. Among smokers, while the rest of them were current smokers, with varying daily consumption levels. More than two thirds were unaware of the link between smoking and wrinkles, while nearly one third believed that the effect was minimal, while nearly one quarter thought that it had a severe impact. Also, most of smoking participants  expressed a desire to learn more about the relationship between smoking and skin aging, and more than half were willing to participate in educational activities related to this topic and  wanted to engage in activities to help them quit smoking. Conclusion: In conclusion, the study highlights a critical gap in awareness about the detrimental effects of smoking on skin health among Najran city residents, alongside a willingness to engage in educational programs. These findings underscore the need for targeted health education campaigns to inform the community about the risks associated with smoking and to encourage healthier lifestyle choices.