Background: Electronic learning enables students to engage with educators more readily, fostering a less formal learning atmosphere than traditional classroom settings. This mode of learning offers greater flexibility compared to conventional methods, as e-learning materials are more accessible at any time and place. Students' self-efficacy plays a significant role in influencing their perceptions, thoughts, and actions toward e-learning. Aim: This study aimed to assess the level of nursing students` self-efficacy toward using e-learning. Research design: A descriptive exploratory design was used. Setting: The study was conducted in faculty of nursing at Al-Azhar University. Subjects: 376 nursing students from second, third and fourth years in faculty of nursing of the above mentioned setting were included in the study. Tools of data collection: Data were collected by using two tools, Students demographic, equipment support and technical data form and self-efficacy questionnaire. Results: 27.4% of studied nursing students had high-self efficacy, 50.3% of them had average self- efficacy toward using e-learning and 22.3% of them had low self-efficacy toward using e-learning. Conclusion: There was highly a statistical significant relation between the studied nursing students' total self-efficacy level toward using e-learning and their demographic data at p< 0.001^**. Recommendations: Ongoing educating the academic nursing students about how to use e-learning platforms to transform them into the future through various media as well as the faculty members to help them become more knowledgeable and skilled.