Background: post-surgical complications following transurethral resection of the bladder cancer are numerous and can lead to life threating problems for patient. Aim of the study: was to evaluate the effect of self-care guidelines on potential post-operative complications after transurethral resection of the bladder cancer. Study design: A quasi-experimental research design was established to achieve the aim of the study. Setting: At in- patient Urology Ward 7 and 8 and urology clinic outpatients in El Demerdash Hospital Ain-shams University Cairo- Egypt. Subjects: A Purposive sample of 66 patients was enrolled. Tools: data were collected using three tools as follow: (I): Patient Assessment questionnaire, (2): Patient`s self-care practices reported questionnaire and (3): complication assessment questionnaire.  Results. The result of this study proved that, There was statistically significant improvement for patient`s knowledge regarding bladder cancer and TURBT, self-care practices and significant decreasing in occurrence of post-operative complications. Conclusion: the self-care guidelines had a positive effect on patient`s knowledge and decrease the occurrence of post-operative complications. Recommendations: periodic education about transurethral resection of bladder cancer should be performed for patient with bladder cancer.