Background: Premarital counseling has significant role in prevention of genetic disorders, congenital anomalies several medical, and psychosocial marital problems. Aim of the study: Evaluate the effect of educational program about premarital counseling for nursing school students. Research design: A Quasi- experimental study used to achieve the aim of current study. Sample: A convenient sample of 120 students used this in study. Setting: Nursing school's students at Minya governorate. Tool: Two tools used to achieve the aim of this study: 1^st tool: Interviewing questionnaire sheet which consisted of three parts demographic characteristics of student, medical history, and knowledge of student about premarital counseling, 2^nd tool: Reported practices of student for premarital counseling. Result: There was a marked improvement in total student's knowledge as the pre-educational program was (62.4%-32.3%-5.3%) improved to (12.5%-10%-77.5%) during post-educational program, respectively, there were marked improvement in the practices post-educational program from one most (98.3 %) of the student has satisfactory practices with pre-educational program to (100 %) with post-educational program. Conclusion: The results of present study supported the research hypothesis that there is marked an improvement in knowledge, and reported practices toward premarital counseling for nursing school students after implement an educational program. Recommendation: Apply health education program for couples who will obtain a health certificate for marriage.