Background: A full year without menstrual blood is known as menopause, if there has been no surgery or medical condition such as hormonal birth control, radiation therapy, or surgical ovarian excision that may halt the bleeding. It comes with growing older.. The aim: The study aimed to investigate the effectiveness of health promoting based program versus artificial intelligence based program on knowledge and quality of life among menopausal women. Design: Quasi-experimental study was utilized. Setting: The study was conducted at gynecological outpatient clinic at obstetric at gynecological hospital, Ain Shams University, Egypt. Sample: Purposive sampling of 100 peri menopause and menopausal women. Tools: Structured interviewing questionnaire: Part A: Socio-demographic characteristics for women. Part B: Women medical history, Part C: Women knowledge regarding menopause. Part D: Menopause Specific Quality of Life Questionnaire (MENQOL): Results: The current study reveals there are statistically significant differences regarding total knowledge between two groups (p value < 0.042), statistically significant differences between physical domains at (P value < 0.025, Psy-social domain at (P value < 0.047) between two groups. Conclusion: Implementation of the health promoting based program improved menopausal woman knowledge and their quality of life compared to implementation of artificial intelligence based program. Recommendations: The present study recommended that, the health promoting based program have to be applied to all women health care settings as the best methods and a template for teaching women about the menopause.