Background: Chronic gastritis is a global health issue that is frequently associated with a variety of complications and is a highly prevalent digestive tract disease that affects individuals of all ages worldwide. Chronic gastritis education is beneficial for patients, as it provides them with additional information to enhance their quality of life and self-efficacy. Aim of the study: To assess the effect of educational Intervention on self-efficacy and quality of life among patients with chronic gastritis  Design: A Quasi experimental design was used for conducting the study. Setting: The research  was conducted in the medical department and medical outpatient clinic at Benha University Hospital, Egypt. Sample: A purposive sample of 112 adult chronic gastritis patients divided to 2 equal groups: Intervention group (56 patients) and control group (56 patients) were selected according to inclusion criteria. Tools: three tools were utilized for data collection 1) A structured interviewing questionnaire 2) self-efficacy Scale and 3) Quality of Life Scale. Results of this trail showed that knowledge, self-efficacy and Quality of Life not significantly different among intervention and control groups pre intervention, while were statistically and significantly different post educational intervention. Conclusion: Implementing the educational intervention had a positive and better effect on patients with chronic gastritis evidenced by increased knowledge score, and improved self efficacy and quality of life mean scores among intervention groups than in control group. Recommendations:  Enhance health education program regarding self-care for patients with chronic and dietary education. Replication of the current study on a large representative sample to achieve generalization of the results.