Background: Helicobacter Pylori remains a serious public health problem, impacts over half of the world's population. The common sense model of self-regulation is a more effective educational model for self-management for Helicobacter Pylori infection progression. Aim: Evaluate the effect of educational program-based on common sense model of self-regulation on self-management of patients with helicobacter pylori infection. Design: A quasi-experimental design was employed in the present study. Setting: The study was conducted in internal medicine outpatient clinic at a governmental hospital affiliated to Suez University Hospital, Ismailia, Egypt. Sample: One hundred adult helicobacter pylori patients were divided into intervention and control groups (50 patients in each group). Methods: Researchers used two study tools to collect data for this study. The first tool was a structured interview questionnaire, which included two parts: Part I gathered personal and medical data, while Part II assessed the patient's knowledge about H. pylori infection. The second tool was a self-management questionnaire designed to evaluate patients' self-management. The researchers implemented an education program based on CSM in three sessions conducted over 10 weeks. Results The study group showed significant improvements in all parameters (P < 0.001), (self-integration (mean increase from 15.92 to 41.78, self-regulation (mean increase from 12.68 to 31.40, interactions with others (mean increase from 12.02 to 31.04, and adherence to the therapeutic regimen (mean increase from 6.84 to 18.64. The study group's overall self-management score rose significantly from 53.00 to 137.54 compared to the control group. The study group's mean knowledge score increased significantly to 4.22 ± 0.84, whereas the control group's score remained nearly unchanged at 1.02 ± 0.51 (t = 22.97, P < 0.001, effect size δ = 6.22) compared to the control group. Conclusion: There was a statistically significant improvement in knowledge and self-management in the study group compared with the control group after implementation of education program-based on self-regulation common sense model. Recommendation: Education program-based on self regulation common sense model should be conducted for helicobacter pylori patients as they are the key to improve self-management.