Background: Tracheal intubation is an important measure to rescue and treat critically ill patients. Tracheal cuff pressure management is an important part of artificial airway management, and is closely related to the prevention of aspiration, ventilator-associated pneumonia (VAP), and other complications. Aim: determine the effect of body position changes on endotracheal tube cuff pressure measurements for mechanically ventilated patients. Study design: A quasi-experimental design. Setting: This study was conducted at Surgical Intensive Care Unit of Emergency Tanta University Hospital and Surgical Intensive Care Unit of Tanta International Teaching Hospital. Subjects: A purposive sample of 100 adult mechanically ventilated patients who were meeting all inclusion criteria was selected. Tools: Tool (I): mechanically ventilated patients' assessment. Tool II: endotracheal tube cuff pressure assessment. Tool (III):  physiological parameters assessment. Results: revealed that significant differences were found between endotracheal tube cuff pressure mean scores measured in left lateral position and right lateral position post 10 minutes, 20 minutes, 45 minutes, and 90 minutes from each position change. Conclusion: The cuff pressure measurements were significantly changed with changing the patients' body positions at different timing. Recommendations: cuff pressure has to be checked post patients' body position changes and adjusted to the prescribed limits to prevent complications and replication of the study on large probability sampling.