Background: Career maturity is one of the most crucial components of supporting one's future career growth; Resilience in nursing has been highlighted as a human characteristic that assists nurses in dealing with professional difficulties and responsibilities. Define psychological resilience as the ability to mentally cope with or adapt to uncertainty, challenges, and adversity. It is sometimes referred to as “mental fortitude." Aim: The current study aimed to assess career maturity and its effect on psychological resilience among head nurses. Research design: A descriptive correlational design was used to carry out this study. Setting: This study was conducted at Ain Shams University Hospital. Subjects: This study  included (80) head nurses from the aforementioned setting, and used a simple random sampling technique. Tools of data collection: The current study used  two tools namely; Career maturity Questionnaire and Connor-Davidson Resilience scale. Results: Approximately two thirds (64%) of studied head nurses had high Psychological Resilience, and the majority of them (87.5%) had high career maturity. Conclusion: There were statistically significant relations between head nurses' psychological resilience and all dimensions of career maturity and overall resilience. Recommendations: The present study provide suggestions for the development of future research and strategies aimed at improving the career maturity of nurses and improving  Psychological Resilience.