Background: The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a "public health emergency of international concern. Aim: Is to assess the awareness of health care provider towards COVID 19 vaccine at Suez Canal university hospital. Research design: A descriptive design was utilized in the study. Setting: The study was conducted in Suez Canal University Hospitals at Ismailia Governorate, Sampling A convenient sample composed of composed of (341) all available health care providers (nurses and physicians) Tools: two tools were used for data collection First tool: Self-administered questionnaire through Google forms were distributed by the researcher through social media and WhatsApp groups, included four parts: Part I: Sociodemographic characteristics. Part II: History of health care providers regarding COVID 19 vaccine. Part III: Knowledge of health care providers regarding COVID 19. Part IV: Reported practices of health care providers toward COVID 19 vaccine. Second tool: Likert scale adapted from Zhong et al. (2020) for assessing attitude of health care providers toward COVID 19 vaccine. Results: The main results of study revealed 94% of HCPs had satisfactory level of knowledge while 6% of them had unsatisfactory level of knowledge. 54% of HCPs had healthy reported practices while 46% of them had unhealthy reported practices. Additionally 98% of HCPs had positive attitude while 2% of them had negative attitude toward COVID 19 vaccine. Conclusions there was a highly statistically significance correlation between total level of reported practices and total level of knowledge of health care providers HCPs regarding COVID 19 vaccine in which p> 0.000. Moreover, it shows that there was a statistically significance correlation between total level of attitude and total level of knowledge of HCPs regarding COVID 19 vaccine. Recommendation: Further studies should be conducted to raising health care providers awareness through educational program about COVID-19 vaccination as a disease-control method, reducing hesitation toward vaccination