Background: Total hip replacement is one of the most cost-effective and consistently successful surgeries performed in orthopedics. It provides reliable outcomes specifically pain relief, functional restoration, and overall improved patient's health status. Aim of the study: Assessment of relation between patients' compliance and their outcomes post total hip replacement surgery. Research design: Descriptive correlation study was utilized. Setting: The study was conducted at orthopedic surgery departments (2, 3) and joint outpatient clinic in El Demerdash hospital affiliated to Ain Shams University Hospitals. Subjects: A purposive sample of (50) patients post total hip replacement. Tools: Four tools were used in the current study: 1) Patient structured interview questionnaire, 2) Patients' knowledge regarding joint replacement tool, 3) Patients' compliance assessment tool. And 4) Western Ontario and Mac Master Universities Arthritis Questionnaire Results: (68.0%) of the studied patients have unsatisfactory total level of knowledge regarding the joint replacement, (80.0%) of them were non-compliant regarding post total hip replacement surgery, Also, (46%) of them had mild total outcomes post total hip replacement. Also, there was a highly statistically significant relation between total patient's level of knowledge, level of compliance and total outcomes post total hip replacement surgery. Conclusion: It can be concluded that, there were positive correlation between total level of knowledge score and total compliance score regarding post total hip replacement surgery among the studied patients. Meanwhile, there was a negative correlation between total outcomes score and total level of knowledge and compliance score regarding post total hip replacement surgery. Recommendations: A simplified and comprehensive guidelines booklet or pamphlet illustrating all instructions the patient may need post total hip replacement surgery.