Background : Occupational stress and Organizational commitment are very significant for ensuring sustained productivity from the employee of an organization. Aim of the study: to find out the relationship between occupational stress and organizational commitment among staff nurses. Subjects and methods : this is a descriptive correlational design was conducted at Ashmoun fever hospital in Menofiya in Egypt on a sample of 80 staff nurses. Data were collected through using a self-administered tool with stress rating scale and organizational commitment questionnaire . Results: there was a highly significant statistical moderate negative correlation between study participants' total organizational commitment and their occupational stress,  more than two thirds (67.5%) of participants had high level of total occupational stress and near half (47.5%) of them had high level of total organizational commitment . Conclusion: There was significant statistical relationships between study participants' level of total occupational stress and total organizational commitment and their characteristics .There was a highly significant statistical moderate negative correlation between study participants' total organizational commitment and their occupational stress. Recommendations: The study findings recommended that, develop strategies for improving nurses working conditions.