Background:  Women with hysterectomy suffer from many psychological and emotional problems. the psychological state and coping strategies of post-hysterectomy women are unclear and need to be identified. So, the Aim of the current study was: To determine the effect of educational guidelines about coping strategies on anxiety and depression among women post-hysterectomy. Design: A quasi-experimental research design was used to fulfill the aim of this study (one group pre-test-post-test design). Setting: The study was conducted in the obstetric and gynecologic department at Mansoura University Hospital. Subjects: Based on the non-probability purposive sampling technique, a sample of fifty women with hysterectomy was selected. The following criteria were used to choose the women post-hysterectomy who participated in this study. Tools: Tool (I):- A structured interview questionnaire, Tool (II): The Zung Self-rating Anxiety Scale, Tool (III):- The Zung Self-rating Depression Scale, and Tool (IV):- The Brief COPE Scale Results: Findings revealed that there was a highly statistically significant reduction in the anxiety and depression among women post-hysterectomy after educational guidelines about coping strategies implementation than before implementation. Conclusion: The result was concluded that implementation of the educational guidelines about coping strategies had a positive effect on reducing anxiety and depression among women post-hysterectomy after implementation compared to before. Recommendations: Generalization of educational guidelines about coping strategies for all women post- hysterectomy to alleviate their reduced anxiety and depression. establishing emotional support groups to help women go through their feelings and worries about undergoing a hysterectomy and supplying accurate information about hysterectomy that covers both medical and mental health care