Aim of the study: The study aimed to assess the nurse's performance for care of neonate's with cyanotic congenital heart disease. Research design: Descriptive design was used. Sample: A convenient sample included all available nurses at the NICU. Setting: This study was conducted at neonatal intensive car unite at Maternity& Pediatric hospital affiliated to Ain Shams University Hospital and Abo EL-Rish Hospital affiliated to Cairo University Hospital. Tool: Three parts were used for data collection (1) predesigned questionnaire format, include the demographic characteristics of studied nurses, and studied newborn. (2) Assessment of nurse's knowledge about cyanotic congenital heart disease. (3) Attitude assessment scale. Result: shows that the mean age of studied nurses was 25.76±2.80 years, and near two thirds (62.9% & 61.4%) of them were males and had bachelor's degree respectively. Conclusion: Nearly to two thirds of nurses had average knowledge, less than half of them had poor knowledge and more than one tenth of them had good knowledge about care of newborn with cyanotic congenital heart disease. Recommendations: Design training courses for nurses to improve their knowledge, practice, and attitude about cyanotic congenital heart disease.