Background: Pain originating from intramuscular (IM) injection must not be underestimated. Nurses commonly administer intramuscular injections, which can be painful and distressing for patients. The Helfer skin Tap Technique can help lessen the pain associated with these injections. Aim: To evaluate the effect of Helfer Skin Tap Technique on pain perception and trypanophobia among patients taking analgesics. Design: Pre-posttest quasi-experimental research design was utilized to achieve the aim of the current study.  Setting: The current study was conducted in general surgical departments at Elkasr AlEini University Hospital, Egypt. Sample: A purposive sample of one hundred (100) adult male and female patients receiving intramuscular analgesics injection, and fulfilled the inclusion criteria. Tools: Three tools were utilized: (1) Demographic and Medical Data Sheet, (2) Numerical Pain Rating Scale, and (3) Anxiety Rating Scale. Results: Highly statistical significant differences were observed between the two interventions (Standard Technique and Helfer Skin Tap Technique) in relation to pain and anxiety levels. Conclusion: Helfer Skin Tap Technique is effective in reducing pain and alleviating anxiety among patients regarding intramuscular injection. Recommendation: The study should be conducted among adult patients undergoing various types of injection and different intramuscular sites.