Background: Hepatocellular carcinoma (HCC) is the 4th most common cancer in Egypt and is the 2nd leading cause of cancer-related death in both men and women. Aim: To evaluate the effect of the instructional scheme on health outcomes among patients with hepatocellular carcinoma. Research design: A quasi-experimental research design was used for this study (Pre-test post-test design). Sample: A convenient sample of 50 patients of both sexes with hepatocellular carcinoma. Setting: The study was applied in the Tropical Medicine& Gastroenterology Department and outpatient clinic at Sohag University Hospital. Tools:  (1) Personal and Health related data Questionnaire, (II) The Karnofsky Performance Scale, (III) Functional Assessment of Cancer Therapy- for Hepatobiliary cancer patients (FACT-Hep Questionnaire).  Results: Following the implementation of the instructional scheme, patients' Karnofsky Performance Scale (KPS) scores significantly increased compared to the instructional scheme implementation (p-value <0.001). Conclusion: instructional scheme implementation effectively improves health outcomes among patients with hepatocellular carcinoma. Recommendations: Incorporate instructional scheme implementation about hepatocellular carcinoma to improve patients' health outcomes. Replication of nursing intervention of this study on a larger probability sample