Children with chronic kidney disease undergoing hemodialysis therapy experience various physical and mental problems that contribute to psychological disorders such as pain and anxiety. It can affect the mental and physical components of poor quality of life. Pain and anxiety among children on dialysis is an important issue to be discussed, in addition to how eye movement exercise application can help in making this through the pediatric nurse. Hence, this study aimed to evaluate the effectiveness of eye movement exercise application on pain and anxiety among children undergoing hemodialysis. Research design: A quasi-experimental research design was used to achieve the aim of the current study. Setting: The study was conducted in the Pediatric Nephrology Unit at Sohag University Hospital. Sample: A purposive sample that included all 100 children on dialysis was selected. Tools: three tools were used: Tool (I) included children's personal data, and medical record sheets of the studied children, Tool (II) included the Numeric Pain Rating Scale, and Tool (III) included the Hamilton Anxiety Rating Scale. Results: A highly statistically significant difference and reduction were found regarding the total mean scores of pain and anxiety among children undergoing hemodialysis, where the children had low total mean scores of pain and anxiety levels after receiving eye movement exercise, compared to post-eye movement exercise application. Conclusion: It can be concluded that eye movement exercise application had a positive effect in reducing pain and anxiety among children undergoing hemodialysis. Recommendation: eye movement exercise application, It is suggested to be incorporated into the daily nursing practice for the management of psychological problems in children undergoing hemodialysis to reduce pain and anxiety.