Background:  Acupressure is used in traditional Chinese medicine to apply pressure to certain points which is believed to decrease nausea and vomiting. Aim: to examine effect of band- aid combined with expectancy manipulation instructions on pregnancy related nausea and vomiting. Design: a comparative quasi-experimental was used.  Setting: This study was conducted at antenatal outpatient clinics at Minia University Hospital. Subjects: a purposive sample of 120 pregnant women who are currently experiencing nausea and vomiting were selected.  Tools: The data were collected using three tools: a structured interview questionnaire, the pregnancy unique quantification of emesis (PUQE) scale and nausea severity expectancy and perceived susceptibility tool. Results: The current study found a statistically significant variation in the severities of nausea and vomiting during the post-intervention stage in contrast to the pre-intervention stage in favor of the acupressure band- aid with expectancy-enhancing instructions p≤ 0.05. Also, nausea severity expectancy and susceptibility decreased in the acupressure band- aid with expectancy-enhancing instructions group than  in the acupressure band- aid with expectancy-neutral instructions and the control groups. Conclusion: acupressure band- aid applied on umbilical area combined with instructions expectancy manipulation has good effect on reducing nausea and vomiting severity, expectancy and susceptibility. Recommendation: acupressure band- aid applied on umbilical area must be taught to maternity nurses for managing women complaining from nausea and vomiting to lower the dangers of taking antiemetic medications in the first trimester.