Background: Breast cancer is the most common disease in women, and it poses risks to a wide range of areas of a person's health, including their mental and physical health, their sexual function, and their sexual happiness. Aim: Evaluate the Effectiveness of Group Counseling Based on Problem Solving on Sexual Function, Quality of Life and Sexual Satisfaction of Women After Mastectomy. Methods: Quasi - experimental research design (Pre-test and post-test) was used in this study. It was conducted at outpatient clinic of the South Egypt Cancer Institute, Assiut University. Sample: a purposive sampling of 50 participants after mastectomy were included in the study. Four tools were used: structured interview questionnaire, Female Sexual Function Index, Married Women's Sexual Satisfaction Scale and Medical Outcomes Study 12-Item Short-Form. Results: The findings from this study showed a significant improvement in the means score of the total and scores of all domains of sexual function and quality of life after intervention. Also, the findings of the present study showed a significant difference in the increase of sexual satisfactions among women undergoing mastectomy surgery after intervention. Conclusion:  Sexual counseling was statistically increasing the mean score of sexual function, sexual pleasure, and quality of life. Recommendations: A randomized controlled trial on continuing sexual health counseling programs for breast cancer survivors with a large sample is recommended.