Background: Bladder problems frequently occur among individuals with multiple sclerosis and can cause significant distress. However, these symptoms could be effectively treated. Nurses play a crucial part in managing bladder dysfunction by advocating for a comprehensive care strategy, which can enhance bladder management and alleviate patient concerns. Aim of the study: To examine the urinary symptoms encountered patients with multiple sclerosis and develop nursing guides for managing these symptoms. Design: A descriptive research approach was used. Setting: The research carried out at Zagazig University Hospital's Neurology Outpatient Clinics. Subjects: Study enrolled a total of 100 patients diagnosed with multiple sclerosis. Tools: Four instruments were used: 1) Patient assessment form, 2) Quality of life module for lower urinary tract symptoms by the international consultation on incontinence, 3) Short form urinary incontinence questionnaire, and 4) Nursing guides regarding urinary symptoms. Results: The findings revealed that 61% of studied clients aged ≥ 30 years old and graduated from secondary school. The biggest proportion of studied sample was females, and 70% of them were unemployed. Findings also demonstrated that a significant correlation between onset of disease regarding Total ICIQ-LUTS.qol score, ICIQ-UI-short form, Overall interference of leaking urine with daily life. Conclusion: Study concluded that bladder problems related to multiple sclerosis had a negative effect on about half of studied patients' lives. Recommendation: It was suggested that all nurses should be trained on effective intervention for multiple sclerosis patients to enhance their standard of living and also to empower their management of urinary problems.