Background: Pregnancy is a unique experience in a woman's existence that is accompanied by major physiological, biochemical, and psychological changes that may have an impact on mental health. Implementing complementary therapy (music therapy) throughout pregnancy enhance psychological status and sleep quality of pregnant women, hence improve postpartum and child wellbeing. Aim of the study: Investigate the effect of music therapy on psychological status, and quality of sleep among pregnant women. Design: A randomized controlled trial (RCT) used to carry out this study. Setting: This study was carried out at an outpatient Medical National Institute in Damanhur. Subjects: 80 pregnant women in third trimester, the pregnant women will be attributed to the music (n=40) and control groups (n=40). Tools: The researchers used three tools to obtain the data that was needed; tool I: Basic data structured interview schedule, tool II: Depression, Anxiety, and Stress Scale (DASS), tool III: Pittsburgh Sleep Quality Index (PSQI). Results: The difference in the level of anxiety, stress, depression and sleep quality between control and the study groups after the music therapy intervention was statistically significant. Conclusion: Music therapy can effectively improve psychological status and quality of sleep among pregnant women in third trimester.