Background: Abortion history has negative psychological impacts on women who might experience an increased anxiety and depression or post-traumatic stress anxiety disease which could be associated with less effective self-care management during pregnancy later on. Psycho educational interventions for the psychological disorders are a multifaceted approach promoting adaptive behaviors in these miserable experiences of abortion for pregnant woman Aim: The study aimed to evaluate the effect of tailored psycho-educational intervention on depression and anxiety levels among pregnant women with spontaneous abortion history. Method: Quasi-experimental research design (nonequivalent control group with pretest/posttest technique) was utilized. Purposive sample of (80) pregnant women with spontaneous abortion history were recruited in the study. The study was conducted at the antenatal ward of obstetrics and gynecology of National Institute of Damanhur-El-Behera governorate, Egypt. Three tools were utilized in the study; Structured Interview Questionnaire, Beck Anxiety Inventory (BAI) and Zung Self-Rating Depression Scale. Results: The study results revealed that there was no significant difference between the intervention and control group regarding most of socio-demographic characteristics and obstetric histories. The results of the current study also reported that there were highly statistical significant differences between intervention and control group pre, and after one and two months of intervention related to anxiety and depression levels (P-value < 0.02 and 0.001; 0.006 and 0.001) respectively. Conclusion: The pregnant women with spontaneous abortion histories who were participated in that tailored psycho-educational intervention exhibit less anxiety and depression levels than those who do not receive it in the control group. Recommendation: A tailored psycho-educational intervention could be utilized by psychiatric and midwives nurses to decrease anxiety and depression levels during antenatal care for pregnant women with spontaneous abortion history.