Background: Cancer breast is a most type of cancer in women worldwide; mindful has been applied to enhance cancer care by get better psychological well-being, quality of life and psychosocial adjustment among women with cancer receiving chemotherapy-induced alopecia. Aim: to examine effect of mindfulness based intervention on alopecia distress, body image changes and health related quality of life among women with breast cancer. Design: quasi-experimental design (pre- posttest single group). Subjects: a purposive sample of 110 women with chemotherapy induced alopecia. Setting: Outpatient clinics in Oncology Institute, Menoufia University, Egypt. Instruments: five instruments consisted of interviewing questionnaire comprised socio-demographic properties and clinical data, chemotherapy induced alopecia distress scale, mindful attention awareness scale, coping with body image changes inventory and health related quality of life questionnaire. Results: On pre intervention the level of higher distress was 89.1% reduced to 10.9% on post intervention beside, there was high statistical significant difference between total mean scores of alopecia distress p= .000 on pre and post intervention. Moreover, there was an statistical significant difference between pre and post intervention regarding to the total mean score of coping with body image changes p = .000. Additionally, the good quality of life level was 40.0% before intervention which improved to 63.6% after intervention as well there was an statistical significant difference between pre and post intervention p= .000. Furthermore, on post intervention there was significant negative correlation between mindful attention awareness and alopecia distress R= -.338- & p=.002 and health related quality of life R=-.374-& p=.000. Also, there was significant positive correlation between mindful attention awareness and coping with body image changes R=.323 & p= 0.003. Conclusion: mindfulness intervention has significant positive effects outcomes on alopecia distress, coping with body image changes and health related quality of life in cancer breast women with chemotherapy induced alopecia. Recommendations: usage of mindfulness intervention as a mean in management plan for women with cancer breast.