Background: Adolescents with multiple sclerosis (MS) report lower health-related quality of life (HRQoL) as compared to general and other chronic disease populations. The aim of the study was to assess quality of life for multiple sclerosis among Adolescents. Research design: Descriptive design. Settings: This study was conducted in MS unit at Ain Shams University Hospital whereas; this unit has a large number of adolescences with MS. Subjects: A Purposive sample of 50 adolescents suffered from MS. Tools: 1^st tool; Structure interview questionnaire included demographic characteristics. 2^nd tool: medical record and 3^rd tool was Multiple Sclerosis Quality of Life for Adolescents (MSQOL)-54. Results: the study revealed that (74.0%) were female, more than one quarter (28%) of them their families had history of multiple sclerosis disease and majority (86.0%) of them total score level of their quality of life was fair. Conclusion: the majority of studied adolescents had had fair quality of life. Recommendation: Provide continuous education training program and illustrative booklet for adolescents with MS. Further investigation is required to examine the impact of MS on the quality of life for caregivers within the families of adolescents affected by the disease.