Background: Individuals suffering from fibromyalgia frequently experience limitations in carrying out everyday tasks. The precise pathological processes driving fibromyalgia remain elusive, yet it often results in a diminished quality of life. The aim of the study aimed to: Assess the effect of fibromyalgia the patient ‘quality of life, and disability. Design: This study used a descriptive research approach. Setting: The research was conducted at the medical facility of Zagazig University's outpatient clinic of the Department of Rheumatology and Rehabilitation. Subjects: The study enrolled a total of 50 fibromyalgia patients. Tools: Three assessment tools were utilized, including 1): a patient evaluation form,2): fibromyalgia impact questionnaire, and 3): Short Form 36 Health-Related Quality of Life Questionnaire was administered. Findings: 85.7±6.7of Patients experienced significant levels of overall disability associated with fibromyalgia and fibromyalgia disease effects on 66.8 ±5.9 of patients' quality of life. Conclusion: The vast majority of fibromyalgia patients are significantly impacted by disability related disease. As well, about two thirds of patients had negative impact on total QOL. Recommendations: To extend the applicability of the results, replicate this research across diverse settings with a larger sample size of fibromyalgia patients.