Background: The risk of peripheral arterial disease and peripheral neuropathy is markedly increased among individuals with diabetes, Buerger Allen exercise is a simple intervention for improving peripheral circulation. The study was aimed to evaluate the effect of Buerger Allen exercise on lower limb perfusion and peripheral neuropathy among patients with peripheral vascular diseases. Study design: A quasi-experimental design was utilized to conduct this study. Setting: This study was conducted at cardiovascular and endocrinology departments affiliated to Ain Shams university hospitals, affiliated to Ain Shams University, Cairo, Egypt. Sample: A purposive sample of 62 adult patients were selected based on inclusion criteria. Tools of data collection: Patient`s Interviewing questionnaire. Ankle Brachial Index scale. Assessment checklist for selected clinical features of peripheral vascular disease. Michigan Neuropathy Screening Instrument Results: The mean age of the studied patients was 57.16 ± 7.56; males were more prevalent and constituted 69.4% of the studied patients. Also, 43.5% of them were obese. Moreover, there was an improvement in lower limb perfusion among the studied patients post implementation of Buerger Allen exercise with a highly statistically significant difference (P < 0.01). Furthermore, there was an improvement in clinical features of peripheral vascular disease among the studied patients post implementation of Buerger Allen exercise with a highly statistically significant difference (P < 0.01). Also, there was an improvement according to peripheral neuropathy history and symptoms among the studied patients post implementation of Buerger Allen exercise with a highly statistically significant difference (P < 0.01). Conclusion: There was an improvement in ankle brachial index score and peripheral neuropathy symptoms after implementation of Buerger Allen exercise. Recommendations: health education sessions based on evidence guidelines regard Buerger Allen's exercise for improvement of lower peripheral circulation.