Background: Interactions between teachers and their students play a pivotal role in academic engagement as a general and course engagement especially. Aim of the study: It aimed to assess teacher-student interaction and it's relation to nursing administration course engagement among nursing students. Research design: A descriptive correlational design was used to carry out this study. Setting: The study was conducted at Faculty of Nursing-Ain Shams University. Subjects: The study subjects included 133 out of 202 nursing student throughout the academic year (2020-2021) who enrolled in nursing administration course. Tools: Data were collected by using Teacher-Student Interaction Questionnaire and Student Course Engagement Questionnaire. Results: The majority (93.2%) of nursing students had positive behavior regarding teacher-student interaction. In addition, more than three fifth (62.8%) of nursing students had high level of nursing administration course engagement. Conclusion: There was a highly significant statistical positive correlation between total teacher-student interaction and total nursing administration course engagement among nursing students. Recommendations: Using multiple teacher-student communication channels to improve student course engagement,, Offering students the opportunity to engage in classroom projects during class to improve relationships between the student and teacher.