Background: Diabetes is the leading cause of end-stage kidney disease (ESKD), accounting for approximately 50% of patients starting dialysis. However, the management of these patients at the stage of chronic kidney disease (CKD) remains poor, with fragmented care pathways among healthcare professionals (HCPs). Diagnosis of CKD and most of its complications is based on laboratory evidence. Aim: To evaluate the effect of educational guidelines on early detection of chronic kidney failure among diabetic patients. Design: In this study, a quasi-experimental research design was used. Setting: The current study was conducted at the General Medical Departments and Diabetic Out-Patients Clinic at Sohag University Hospital. Subjects: A convenient sample technique of a total of 200 elderly diabetic patients was included in the study. Three tools were used for data collection; Tool (1): Patients' demographic data; Tool (2): Patients' knowledge about chronic kidney failure (pre/post), Tool (3): Patients' reported practice about early detection of chronic kidney (pre/post). Results: The study's findings showed that elderly diabetes patients' reported practices and knowledge of early chronic kidney failure diagnosis differed significantly (highly statistically) between the pre-and post-educational guidelines. Regarding the early detection of chronic kidney failure, there was a statistically significant positive association found between the total knowledge and total practice scores of the elderly diabetic patients under study. Conclusion: Patient knowledge and reported practices regarding early detection of chronic renal failure improved as a result of educational guidelines. Recommendations: Elderly diabetes patients should receive educational programs about the significance of early detection of chronic kidney failure.